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Avesthagen is a leading integrated systems biology platform company that focuses on the convergence of food, pharma and population genetics leading to predictive, preventive, personalized healthcare. Avesthagen employs 500+ people worldwide and is headquartered in Bangalore, India.


Avesthagen has built and continues to build integrated, systems biology approach of capabilities, infrastructure and technology that allows for and facilitates ‘cross talk’ between numerous disciplines, leading to innovative solutions. The business model of the company is to combine IP & product development for long term sustainable revenue generation and value addition, with R&D services and collaborative research programs for/with other parties to generate revenue stream and market focus.


Avesthagen has four strategic business units –


Under bioPharmaceuticals, a substantial pipeline of biosimilars is being developed in partnership with Cipla Ltd. The group focuses on pathway engineering and development of novel expression systems, d evelopment of product specific bioassays and design of novel animal component free production media, generation of over-expressing stable cell lines, development of proprietary expression platforms and novel, scalable processes in microbial and mammalian systems. Scale-up, manufacturing and supply of commercial scale material is done through a joint venture. 200 - 1,000L cGMP facilities have been set-up, several acquisition targets are under review and the first products are expected to reach the market in 2009.


bioNutrition focuses on developing scientifically validated, nutritional bioactives from traditional Indian medicinal plants, for prevention or treatment of degenerative conditions such as diabetes, obesity, CVD and bone health. We also work on performance and stress, skincare and digestion through use of proprietary tools. We target both food and pharma markets and, coupled with marketing strategies developed with global leaders and the acquisition of two businesses, the bioNutrition unit is expending fast.


On the OTC front, we specialize in superior Ayurvedic (indigenous Indian medical science) herbal extract ingredients but we also source botanical biomass from all over the world. Avesthagen has a catalogue of over 40 standardized extracts and multiple grades of innovative specialty products that set the highest standards for purity and concentration of active constituents. Many of our leading products have strong intellectual property positions. These include trademarks and patents that employ process, composition and method of use claims.


On the food side, Avesthagen follows the philosophy of organic, healthy and tasty foods (crackers, bars, muesli, drinks, etc) while adding value by bringing to market product lines prepared using organic ingredients or fortified with clinically validated nutritional bioactives sourced from traditional Indian medicine. Developing products adapted to consumer nutritional needs and tastes has been our commitment from day one.


bioAgriculture focuses on stress resistance and nutrition enhancement in plants. It hosts two wholly owned subsidiaries as well as large collaborations with the Groupe Limagrain and sees itself as a vehicle of seed transmutation, wherein the seeds for the future will be developed through a combination of genetics, breeding, natural and artificial variation and transgenics. Recognizing the cyclical nature of agriculture and research, and the fundamental economics of a profitable enterprise, Avesthagen combines in-house research, joint ventures and client-driven research opportunities to develop the seeds of tomorrow and the requisite technology today in a profitable manner. The in-house programs focus on varieties with value-added traits, capable of being cultivated under adverse conditions as well as nutrition-focused projects. In addition, this division provides large food manufacturers and exporters with testing and certification expertise. Exclusive Licensee of GeneticID USA for India, Pakistan and Bangladesh. Offers plant marker development through assignment of polymorphisms to phenotypes/traits/genes: microsatellite, SNP, RAPD, AFLP, SCAR, SSLP, CAPS etc. Customized Molecular Services: Plant molecular biology, flanking sequence discovery, vector and construct construction, sequencing, promoter cloning, cDNA and BAC library services. Offers licensing opportunities for HybridFITTM, DroughtFITTM, Lyco-PLUS and SalinityFITTM patented technologies.


In Science & Innovation, products and technologies are being developed through collaborative R&D with global partners in the life sciences industry. Over the years several large scale collaborations have emerged from this program and evolved into new ventures. Others have also attracted equity investments in the parent company. The Science & Innovation business unit of Avesthagen employs a Systems Biology approach for the dissection of molecular mechanisms in human diseases and works towards delivery of innovative solutions for predictive, preventive, personalized healthcare. Our competencies in managing the diverse array of technologies in a focused manner by following a multidisciplinary approach enables us to efficiently co-develop novel therapies with our partners in pharma & food business, and academic institutions. The true strength of Avesthagen lies in its dedicated scientific staff, with extensive national and international experience.


To take a product or a technology from concept to market is Science & Innovation’s greatest strength. This path goes across therapeutics areas and is driven by excellence in understanding tomorrow’s market and fully integrating competencies in Genomics, Proteomics, Transcriptomics, Bioinformatics, Metabolomics and Lead Optimisation, Recombinant Protein Expression, Cancer Stem Cells, Diagnostics and Vaccines Development and large scale Population Genomics Programs.


Avesthagen has established world class, state-of-the-art laboratory facilities in India that include, in addition to its general lab space, clean room, a radio isotope labs, a high throughput sequencing and genotyping facilities, a bio safety level P2 green house space for transgenic plant experiments and trials, as well as, through one of its partners, access to irrigated land for field trials. The company is also building its new premises, which will include additional facilities another cGMP unit for pilot and commercial scale manufacturing of bioPharmaceuticals, P3 labs for research on emerging pathogens, pilot scale plant extraction facilities as well as facilities for animal trials.


First mover advantage, strategic positioning and worldwide collaborations saw the company progress towards its goal of bringing new safe medicine faster to the world whilst keeping social and ecological aspects in mind. We, at Avesthagen, recognize that corporate responsibility does not end at the factory gate or at office doors and that economic performance and attention to people go hand in hand.


Avesthagen is backed by reputed investors such as Daninvest (Danone Group, France), bioMérieux (France), Vilmorin & Cie (Groupe Limagrain, France), Fidelity International (USA), New York Life Investment Management India (FVCI) Fund II (USA), ICICI Ventures Funds (India), Tata Industries Ltd. (India), Godrej Industries Ltd. (India), Meditab Specialities Pvt. Ltd (Cipla Group, India) and Bennett, Coleman Co. Ltd. (India).


Avesthagen’s Partners are Danone (France), bioMérieux (France), Limagrain (France), Nestle Nutrition (Switzerland), Imperial College London (UK), CadburySchweppes (UK), Cipla Ltd (India), Godrej Industries Ltd. (India), Quintiles (India), etc.

 

 
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